4-Amino-2-chloropyrimidine
4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (Ki = 0.18 μM) and BChE (Ki = 1.324 μM) . 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC50 = 0.037 μM, Ki = 0.047 μM) in vitro[1][2].
Product Specifications
CAS Number
[7461-50-9]
UNSPSC
12352200
Hazard Statement
H302, H319
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/4-amino-2-chloropyrimidine.html
Purity
99.90
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=NC=CC(N)=N1
Molecular Formula
C4H4ClN3
Molecular Weight
129.55
Precautions
H302, H319
References & Citations
[1]Duran H. E. (2023) . Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry, 70 (1), 68–82.|[2]O'Hare, T., et al., (2004) . Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood, 104 (8), 2532–2539.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Curated Selection
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