Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Cycloleucine

Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][4].

Product Specifications

CAS Number

[52-52-8]

UNSPSC

12352211

Hazard Statement

H301

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cycloleucine.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(O)C1(CCCC1)N

Molecular Formula

C6H11NO2

Molecular Weight

129.16

Precautions

H301

References & Citations

[1]Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC) : a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161 (2-3) :281-2.|[2]Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74 (1) :19-29.|[3]Gargiulo API, et, al. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats. Neuropsychobiology. 2020;79 (3) :191-197.|[4]Dimock K, et, al. Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. Biochemistry. 1978 Aug 22;17 (17) :3627-32.|[5]Duś D, et, al. Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues. Arch Immunol Ther Exp (Warsz) . 1980;28 (3) :433-8.|[6]S Amor, et al. The effect of cycloleucine on SFV A7 (74) infection in mice. Br J Exp Pathol. 1987 Apr;68 (2) :225-35.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-30008/Cycloleucine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-30008/Cycloleucine-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant Human HK2 Protein, His, E.coli-10ug
QP10667-10ug 10ug

Recombinant Human HK2 Protein, His, E.coli-10ug

Ask
View Details
Biotin-Linked Polyclonal Antibody to Protein S (PROS)
LAB971Hu71-01 100 µL

Biotin-Linked Polyclonal Antibody to Protein S (PROS)

Ask
View Details
Biotin-Linked Polyclonal Antibody to Protein S (PROS)
LAB971Hu71-02 200 µL

Biotin-Linked Polyclonal Antibody to Protein S (PROS)

Ask
View Details
Biotin-Linked Polyclonal Antibody to Protein S (PROS)
LAB971Hu71-03 1 mL

Biotin-Linked Polyclonal Antibody to Protein S (PROS)

Ask
View Details
Lentiviral mouse Meaf6 shRNA (UAS) - Lentiviral mouse Meaf6 shRNA (UAS, iRFP) plasmid
GTR15138868 1 Vial

Lentiviral mouse Meaf6 shRNA (UAS) - Lentiviral mouse Meaf6 shRNA (UAS, iRFP) plasmid

Ask
View Details
Anxa13 Rat shRNA Plasmid (Locus ID 362915)
TR708883 1 Kit

Anxa13 Rat shRNA Plasmid (Locus ID 362915)

Ask
View Details