4-Aminosalicylic acid (hemicalcium)

4-Aminosalicylic acid hemicalcium is an inhibitor for dihydrofolate reductase (DHFR) and an antituberculous agent. 4-Aminosalicylic acid hemicalcium exhibits anti-inflammatory activity and can be used in research of inflammatory bowel disease (IBD) . 4-Aminosalicylic acid hemicalcium is orally active[1][1][3].

Product Specifications

CAS Number

[133-15-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-aminosalicylic-acid-hemicalcium.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=C(N)C=C1O.[0.5Ca]

Molecular Formula

C7H7NO3.1/2Ca

Molecular Weight

173.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zheng J, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 9;288 (32) :23447-56.|[2]Abdu-Allah HHM, et al. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem. 2020 Jan;94:103378.|[3]Dhaneshwar SS. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. World J Gastroenterol. 2014 Apr 7;20 (13) :3564-71.