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Org-12962 (hydrochloride)

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].

Product Specifications

CAS Number

[210821-63-9]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/org-12962-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl

Molecular Formula

C10H12Cl2F3N3

Molecular Weight

302.12

References & Citations

[1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128 (1) :13-20.|[2]Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8 (3) :161-8.|[3]Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263 (1-2) :113-22.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-21994/Org-12962-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-21994/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor; α-1 microglobulin

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