PF-562271 (hydrochloride)

PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively[1].

Product Specifications

CAS Number

[939791-41-0]

Product Name Alternative

VS-6062 (hydrochloride)

UNSPSC

12352005

Target

FAK; Pyk2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pf-562271-hydrochloride.html

Purity

98.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CS(=O)(N(C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)C)=O.[H]Cl

Molecular Formula

C21H21ClF3N7O3S

Molecular Weight

543.95

References & Citations

[1]Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68 (6), 1935-1944.|[2]Crompton BD, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73 (9) :2873-83.|[3]Bagi CM, et al. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer. 2008 May 15;112 (10) :2313-21.