3’-O- (t-Butyldiphenylsilyl) thymidine
3’-O- (t-Butyldiphenylsilyl) thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[83467-48-5]
UNSPSC
12352211
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-o-t-butyldiphenylsilyl-thymidine.html
Solubility
10 mM in DMSO
Smiles
[TBDPSO][C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C10H13DTBN2O5PS
Molecular Weight
320.10
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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