Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Derazantinib (dihydrochloride)

Derazantinib (ARQ-087) dihydrochloride is an ATP competitive and orally activeFGFR inhibitor (IC50s: 1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3) . Derazantinib dihydrochloride inhibits FGFR phosphorylation. Derazantinib dihydrochloride inhibits tumor growth in multiple xenograft models[1][2].

Product Specifications

CAS Number

1821329-75-2

Product Name Alternative

ARQ-087 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/derazantinib-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1.Cl.Cl

Molecular Formula

C29H31Cl2FN4O

Molecular Weight

541.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hall TG, et al. Preclinical Activity of ARQ-087, a Novel Inhibitor Targeting FGFR Dysregulation. PLoS One. 2016 Sep 14;11 (9) :e0162594.|[2]Balek L, et al. ARQ-087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3. Bone. 2017 Dec;105:57-66.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Fyn Rabbit Monoclonal Antibody [Clone ID: R07-9I2]
TA384273 100 µL

Fyn Rabbit Monoclonal Antibody [Clone ID: R07-9I2]

Sign In for Pricing
View Details
Tissue FFPE Sections, Ovary: right
CS708885 5x 5 µm

Tissue FFPE Sections, Ovary: right

Sign In for Pricing
View Details
OR52K1 Antibody
8G858-AAT 50 µg

OR52K1 Antibody

Sign In for Pricing
View Details
CLDND1 (NM_001040200) Human Over-expression Lysate
LY421725 100 µg

CLDND1 (NM_001040200) Human Over-expression Lysate

Sign In for Pricing
View Details
2,6-Dichloro-9-(2’,3’,5’-tri-O-acetyl-beta-D-ribofuranosyl)purine
TRC-D435850-5G 5 g

2,6-Dichloro-9-(2’,3’,5’-tri-O-acetyl-beta-D-ribofuranosyl)purine

Sign In for Pricing
View Details
MIR181d Human qPCR Primer Pair (MI0003139)
HP300186 200 Reactions

MIR181d Human qPCR Primer Pair (MI0003139)

Sign In for Pricing
View Details