AIC-292
AIC-292 is a potent and selective inhibitor of HIV-1 nonnucleoside reverse transcriptase. AIC-292 inhibits wild-type HIV-1 laboratory strains at low nanomolar concentrations. AIC-292 displays potent antiviral in vivo efficacy in a mouse xenograft model. AIC-292 has the potential for the research of HIV-1 infection[1].
Product Specifications
CAS Number
[1187917-12-9]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aic-292.html
Solubility
10 mM in DMSO
Smiles
O=C1NCN(C(C2=NN(C3=CC=C(F)C(Cl)=C3)C(C4=CC(F)=CC(Cl)=C4)=C2)=O)C1
Molecular Formula
C19H12Cl2F2N4O2
Molecular Weight
437.23
References & Citations
[1]Wildum S, et al. In vitro and in vivo activities of AIC292, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2013;57 (11) :5320-5329.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
HIV-1
Curated Selection
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