GSK1521498
GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents[1].
Product Specifications
CAS Number
1426543-84-1
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk1521498.html
Solubility
10 mM in DMSO
Smiles
FC1=C(CNC2CC3=C(C=CC=C3)C2)C(F)=CC(C4=CC=CC(C5=NC=NN5)=C4)=C1.O=P(O)(O)O
Molecular Formula
C24H23F2N4O4P
Molecular Weight
500.43
References & Citations
[1]Giuliano C, et al. The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. Neuropsychopharmacology. 2015 Dec;40 (13) :2981-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
μ Opioid Receptor/MOR
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