ABT-288
ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has Ki values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research.[1].
Product Specifications
CAS Number
948845-91-8
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abt-288.html
Solubility
10 mM in DMSO
Smiles
CN1C[C@]2([H])N(C3=CC=C(C4=CC=C(N5C(C=CC=N5)=O)C=C4)C=C3)CC[C@]2([H])C1
Molecular Formula
C23H24N4O
Molecular Weight
372.46
References & Citations
[1]Esbenshade TA, et al. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther. 2012 Oct;343 (1) :233-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
H3 Receptor
Available Sizes
Frequently Asked Questions
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