Sandramycin
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity[1][2][3].
Product Specifications
CAS Number
100940-65-6
UNSPSC
12352005
Target
ADC Payload; Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/sandramycin.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](C(OC[C@@H](NC(C1=C(O)C=C(C=CC=C2)C2=N1)=O)C3=O)=O)N(C)C(CN(C)C(CNC([C@@H]4CCCCN4C([C@@H](COC([C@H](C(C)C)N(C)C(CN(C)C(CNC([C@H]5N3CCCC5)=O)=O)=O)=O)NC(C6=C(O)C=C(C=CC=C7)C7=N6)=O)=O)=O)=O)=O
Molecular Formula
C60H76N12O16
Molecular Weight
1221.32
References & Citations
[1]J A Matson, et al. Sandramycin, a Novel Antitumor Antibiotic Produced by a Nocardioides Sp. Production, Isolation, Characterization and Biological Properties. J Antibiot (Tokyo) . 1989 Dec;42 (12) :1763-7.|[2]Katsushi Katayama, et al. Total Synthesis of Sandramycin and Its Analogues via a Multicomponent Assemblage. Org Lett. 2014 Jan 17;16 (2) :428-31.|[3]D L Boger, et al. DNA Binding Properties of Key Sandramycin Analogues: Systematic Examination of the Intercalation Chromophore. Bioorg Med Chem. 1999 Feb;7 (2) :315-21.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Polyclonal FUS Antibody [DyLight 350]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
EIA06595m 1 Kit
Mouse von Willebrand Factor cleaving protease (ADAMTS-13/vWF-cp) ELISA Kit
Sign In for Pricing
View Details 