Herboxidiene

Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome[1][2].

Product Specifications

CAS Number

142861-00-5

Product Name Alternative

GEX1A

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/herboxidiene.html

Purity

99.02

Solubility

DMSO : 4 mg/mL (ultrasonic; warming)

Smiles

C[C@H]([C@H]([C@H](O)C)OC)[C@@]1([H])O[C@]1(C)C[C@@H](/C=C/C=C(C)/[C@H]2O[C@@H](CC(O)=O)CC[C@@H]2C)C

Molecular Formula

C25H42O6

Molecular Weight

438.60

Precautions

H315, H319, H335

References & Citations

[1]Pokhrel AR, et al. Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide. Appl Microbiol Biotechnol. 2015;99 (20) :8351‐8362.|[2]Sakai Y, et al. GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities. J Antibiot (Tokyo) . 2002;55 (10) :855‐862.|[3]Miller-Wideman M, et al. Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) . 1992;45 (6) :914‐921.