Aeroplysinin 1
Product Specifications
UNSPSC Description
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].
Target Antigen
Apoptosis; Bacterial; HIV
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/aeroplysinin-1.html
Purity
95.00
Solubility
DMSO : 3.39 mg/mL (ultrasonic;warming)
Smiles
N#CC[C@]1(O)C=C(Br)C(OC)=C(Br)[C@@H]1O
Molecular Weight
338.98
References & Citations
[1]García-Vilas JA, et al. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14(1):1. Published 2015 Dec 22.|[2]Martínez-Poveda B, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203.|[3]Kreuter MH, et al. Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1. Comp Biochem Physiol B. 1990;97(1):151‐158.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19827/Aeroplysinin-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19827/Aeroplysinin-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
28656-91-9
Curated Selection
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