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Aeroplysinin 1

Aeroplysinin 1 ((+) -Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM) . Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].

Product Specifications

CAS Number

28656-91-9

Product Name Alternative

(+) -Aeroplysinin-1

UNSPSC

12352211

Target

Apoptosis; Bacterial; HIV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/aeroplysinin-1.html

Purity

95.00

Solubility

DMSO : 3.39 mg/mL (ultrasonic; warming)

Smiles

N#CC[C@]1(O)C=C(Br)C(OC)=C(Br)[C@@H]1O

Molecular Formula

C9H9Br2NO3

Molecular Weight

338.98

References & Citations

[1]García-Vilas JA, et al. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14 (1) :1. Published 2015 Dec 22.|[2]Martínez-Poveda B, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8 (1) :e55203.|[3]Kreuter MH, et al. Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+) -aeroplysinin-1. Comp Biochem Physiol B. 1990;97 (1) :151‐158.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

HIV-1

Frequently Asked Questions

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