Isofistularin-3
Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin[1].
Product Specifications
UNSPSC
12352203
Target
ADC Payload; Apoptosis; Autophagy; DNA Methyltransferase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isofistularin-3.html
Solubility
10 mM in DMSO
Smiles
COC1=C(Br)[C@H](O)[C@@]2(ON=C(C(NC[C@H](O)COC3=C(Br)C=C([C@H](O)CNC(C4=NO[C@]5(C4)C=C(Br)C(OC)=C(Br)[C@H]5O)=O)C=C3Br)=O)C2)C=C1Br
Molecular Formula
C31H30Br6N4O11
Molecular Weight
1114.01
References & Citations
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
DNMT1; Traditional Cytotoxic Agents
Frequently Asked Questions
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