NSC45586

NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP) . NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons[1].

Product Specifications

CAS Number

[739301-85-0]

UNSPSC

12352005

Target

Akt; Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nsc45586.html

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O

Molecular Formula

C20H18N6O3

Molecular Weight

390.40

References & Citations

[1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347 (2) :516-28.