Zanapezil (fumarate)

Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM) . Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD) [1].

Product Specifications

CAS Number

[263248-42-6]

Product Name Alternative

TAK-147 (fumarate)

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zanapezil-fumarate.html

Purity

99.63

Solubility

10 mM in DMSO

Smiles

OC(/C=C/C(O)=O)=O.O=C(C1=CC=C(CCCCN2)C2=C1)CCC3CCN(CC3)CC4=CC=CC=C4.[x]

Molecular Formula

C25H32N2O.xC4H4O4

References & Citations

[1]K Hirai, et al. Neurochemical effects of 3-[1- (phenylmethyl) -4-piperidinyl]-1- (2,3,4,5-tetrahydro-1H-1-b enzazepin-8-yl) -1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, in rats. J Pharmacol Exp Ther. 1997 Mar;280 (3) :1261-9.|[2]Izzettin Hatip-Al-Khatib, et al. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats. Brain Res. 2004 Jun 25;1012 (1-2) :169-76.