JNJ-42165279 (dihydrochloride)
JNJ-42165279 (dihydrochloride) is aFAAHinhibitor with IC50 of 70 nM and 313 nM for hFAAH and rFAAH, respectively[1].
Product Specifications
CAS Number
1346528-51-5
UNSPSC
12352005
Target
FAAH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jnj-42165279-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4.[H]Cl.[H]Cl
Molecular Formula
C18H19Cl3F2N4O3
Molecular Weight
483.72
References & Citations
[1]Keith JM, et al. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279. ACS Med Chem Lett. 2015;6 (12) :1204-1208. Published 2015 Nov 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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