BMS-795311
BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC50s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively[1].
Product Specifications
CAS Number
939390-99-5
UNSPSC
12352005
Target
CETP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-795311.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@](C1=CC(OC(F)(F)C(F)F)=CC(F)=C1)(C2=CC=C(F)C(OC3CC3)=C2)CC4=CC=CC=C4)C5=CC=C(F)C(C(F)(F)F)=C5
Molecular Formula
C33H23F10NO3
Molecular Weight
671.52
References & Citations
[1]Jennifer XQ, et, al. Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[ (1R) -1- (3-Cyclopropoxy-4-fluorophenyl) -1-[3-fluoro-5- (1,1,2,2-tetrafluoroethoxy) phenyl]-2-phenylethyl]-4-fluoro-3- (trifluoromethyl) benzamide (BMS-795311) . J Med Chem. 2015 Nov 25; 58 (22) : 9010-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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