BMS-795311
BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC50s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively[1].
Product Specifications
CAS Number
939390-99-5
UNSPSC
12352005
Target
CETP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-795311.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@](C1=CC(OC(F)(F)C(F)F)=CC(F)=C1)(C2=CC=C(F)C(OC3CC3)=C2)CC4=CC=CC=C4)C5=CC=C(F)C(C(F)(F)F)=C5
Molecular Formula
C33H23F10NO3
Molecular Weight
671.52
References & Citations
[1]Jennifer XQ, et, al. Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[ (1R) -1- (3-Cyclopropoxy-4-fluorophenyl) -1-[3-fluoro-5- (1,1,2,2-tetrafluoroethoxy) phenyl]-2-phenylethyl]-4-fluoro-3- (trifluoromethyl) benzamide (BMS-795311) . J Med Chem. 2015 Nov 25; 58 (22) : 9010-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV784115 1.0 µg DNA
RPS24P5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details 
MBS2169112-01 0.1 mL
FITC-Linked Monoclonal Antibody to Glutathione S Transferase Alpha 1 (GSTa1)
Sign In for Pricing
View Details MBS2169112-02 0.2 mL
FITC-Linked Monoclonal Antibody to Glutathione S Transferase Alpha 1 (GSTa1)
Sign In for Pricing
View Details MBS2169112-03 0.5 mL
FITC-Linked Monoclonal Antibody to Glutathione S Transferase Alpha 1 (GSTa1)
Sign In for Pricing
View Details MBS2169112-04 1 mL
FITC-Linked Monoclonal Antibody to Glutathione S Transferase Alpha 1 (GSTa1)
Sign In for Pricing
View Details MBS2169112-05 5 mL
FITC-Linked Monoclonal Antibody to Glutathione S Transferase Alpha 1 (GSTa1)
Sign In for Pricing
View Details