Vorozole
Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3].
Product Specifications
CAS Number
129731-10-8
Product Name Alternative
(+) -Vorozole; R83842
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vorozole.html
Solubility
10 mM in DMSO
Smiles
CN1N=NC2=CC=C([C@H](C3=CC=C(Cl)C=C3)N4N=CN=C4)C=C21
Molecular Formula
C16H13ClN6
Molecular Weight
324.77
References & Citations
[1]Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :617-21.|[2]Wiseman LR, et al. Vorozole. Drugs Aging. 1997 Sep;11 (3) :245-50; discussion 251-2.|[3]Lubet RA, et al. Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis. 1998 Aug;19 (8) :1345-51.|[4]Wouters W, et al. Pharmacology of vorozole. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :617-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Aromatase/CYP19A1
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