Isamoltane (hemifumarate)
Isamoltane hemifumarate is a selective antagonist of 5-HT1B receptor, with an IC50 of 39 nM for inhibits the binding of [125I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC50 of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity[1].
Product Specifications
CAS Number
874882-92-5
Product Name Alternative
(±) -Isamoltane (hemifumarate)
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/isamoltane-hemifumarate.html
Solubility
10 mM in DMSO
Smiles
OC(COC1=CC=CC=C1N2C=CC=C2)CNC(C)C.O=C(O)/C=C/C(O)=O.[1/2]
Molecular Formula
C16H22N2O2.1/2C4H4O4
Molecular Weight
332.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3; β adrenergic receptor
Frequently Asked Questions
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