SSR-241586

SSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS) [1][2].

Product Specifications

CAS Number

[1239279-30-1]

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ssr-241586.html

Solubility

10 mM in DMSO

Smiles

O=C(C1(N2CCCCC2)CCN(CC[C@@]3(C4=CC=C(Cl)C(Cl)=C4)CN(C(C5=CC=CC=C5)=O)CCO3)CC1)N(C)C

Molecular Formula

C32H42Cl2N4O3

Molecular Weight

601.61

References & Citations

[1]Métro TX, et al. Asymmetric synthesis of an antagonist of neurokinin receptors: SSR 241586. J Org Chem. 2011 Apr 15;76 (8) :2594-602.|[2]Cochi A, et al. Enantioselective synthesis of SSR 241586 by using an organo-catalyzed Henry reaction. Org Lett. 2010 Aug 20;12 (16) :3693-5.