Besifovir Dipivoxil (maleate)
Besifovir Dipivoxil maleate (LB80380 maleate) is an oral proagent of LB80317. Besifovir Dipivoxil maleate (LB80380 maleate) is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients in preliminary studies[1][2]</sup.
Product Specifications
CAS Number
1039623-01-2
Product Name Alternative
LB80380 (maleate)
UNSPSC
12352005
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/besifovir-dipivoxil-maleate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=C2N=CN(CC3(OCP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)CC3)C2=N1.O=C(O)/C=C\C(O)=O
Molecular Formula
C26H38N5O12P
Molecular Weight
643.58
References & Citations
[1]Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11 (8) :977-83.|[2]Lai CL, et al. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2014 Jun;63 (6) :996-1004.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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