Gastrazole
Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2].
Product Specifications
CAS Number
862583-15-1
Product Name Alternative
JB95008
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gastrazole.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C=C(NC=N1)C1=C2)=C2C(NCC3CCCCCC3)=O)N[C@H](C(NC4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)=O)CC(C=CC=C5)=C5F
Molecular Formula
C34H32FN5Na2O7
Molecular Weight
687.63
References & Citations
[1]Chau I, et, al. Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94 (8) :1107-15.|[2]Rudholm T, et, al. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009 Jan 8;152 (1-3) :8-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CCKBR
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