Cis-ACPD

Cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

Product Specifications

CAS Number

[477331-06-9]

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

IGluR; mGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cis-acpd.html

Solubility

10 mM in DMSO

Smiles

O=C([C@]1(N)C[C@H](C(O)=O)CC1)O

Molecular Formula

C7H11NO4

Molecular Weight

173.17

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis- (+-) -1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56 (5) :1789-96.|[2]Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57 (11) : 889-95.