cis-ACPD
Product Specifications
UNSPSC Description
cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].
Target Antigen
iGluR; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cis-acpd.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]1(N)C[C@H](C(O)=O)CC1)O
Molecular Weight
173.17
References & Citations
[1]Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56(5):1789-96.|[2]Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57(11): 889-95.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19434A/cis-ACPD-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19434A/
Clinical Information
No Development Reported
CAS Number
477331-06-9
Curated Selection
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