2-Methyl-5-HT (maleate)

2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT maleate is shown to display anti-depressive-like effects[1].

Product Specifications

CAS Number

[78263-91-9]

Product Name Alternative

2-Methyl-5-hydroxytryptamine (maleate) ; 2-Methylserotonin (maleate) ; 2-Me-HT (maleate)

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-methyl-5-ht-maleate.html

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C\C(O)=O.OC1=CC2=C(NC(C)=C2CCN)C=C1

Molecular Formula

C15H18N2O5

Molecular Weight

306.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.