2-Methyl-5-HT (hydrochloride)

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].

Product Specifications

CAS Number

[845861-49-6]

Product Name Alternative

2-Methyl-5-hydroxytryptamine (hydrochloride) ; 2-Methylserotonin (hydrochloride) ; 2-Me-HT (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-methyl-5-ht-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC1=CC2=C(NC(C)=C2CCN)C=C1.[H]Cl

Molecular Formula

C11H15ClN2O

Molecular Weight

226.70

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.