SKI2852
SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively[1].
Product Specifications
CAS Number
1346554-47-9
UNSPSC
12352005
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ski2852.html
Purity
98.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(N2[C@H](C)CN(C3=CC=C(S(=O)(C)=O)C=C3F)CC2)=NC=C1)N[C@@H]4[C@]5([H])C[C@@]6([H])C[C@](C5)(O)C[C@]4([H])C6
Molecular Formula
C27H34FN5O4S
Molecular Weight
543.65
References & Citations
[1]Ryu JH, et al. Discovery of 2- ((R) -4- (2-Fluoro-4- (methylsulfonyl) phenyl) -2-methylpiperazin-1-yl) -N- ((1R,2s,3S,5S,7S) -5-hydroxyadamantan-2-yl) pyrimidine-4-carboxamide (SKI2852) : A Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) . J Med Chem. 2016 Nov 23;59 (22) :10176-10189.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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