SKI2852

SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively[1].

Product Specifications

CAS Number

[1346554-47-9]

UNSPSC

12352005

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ski2852.html

Purity

98.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NC(N2[C@H](C)CN(C3=CC=C(S(=O)(C)=O)C=C3F)CC2)=NC=C1)N[C@@H]4[C@]5([H])C[C@@]6([H])C[C@](C5)(O)C[C@]4([H])C6

Molecular Formula

C27H34FN5O4S

Molecular Weight

543.65

References & Citations

[1]Ryu JH, et al. Discovery of 2- ((R) -4- (2-Fluoro-4- (methylsulfonyl) phenyl) -2-methylpiperazin-1-yl) -N- ((1R,2s,3S,5S,7S) -5-hydroxyadamantan-2-yl) pyrimidine-4-carboxamide (SKI2852) : A Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) . J Med Chem. 2016 Nov 23;59 (22) :10176-10189.