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Fmoc-Val-D-Cit-PAB

Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC) [1].

Product Specifications

CAS Number

[1350456-67-5]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-val-d-cit-pab.html

Purity

99.23

Solubility

10 mM in DMSO

Smiles

OCC(C=C1)=CC=C1NC([C@@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O

Molecular Formula

C33H39N5O6

Molecular Weight

601.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Mondal D, et al. Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research. Tetrahedron Lett. 2018;59 (40) :3594-3599.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-19318A/Fmoc-Val-D-Cit-PAB-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-19318A/

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Protease Cleavable Linker

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