DU125530

DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects[1][2].

Product Specifications

CAS Number

[161611-99-0]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/du125530.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=C5OCCOC5=CC(Cl)=C4)CC3)S2(=O)=O

Molecular Formula

C23H26ClN3O5S

Molecular Weight

491.99

References & Citations

[1]Mos J, et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1;325 (2-3) :145-53.|[2]Scorza MC, et al. Preclinical and clinical characterization of the selective 5-HT (1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov;167 (5) :1021-34.