BMS-193884
BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].
Product Specifications
CAS Number
176960-47-7
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-193884.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O
Molecular Formula
C20H17N3O4S
Molecular Weight
395.43
References & Citations
[1]Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[ (4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4- (2-oxazolyl) [1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET (A) selective antagonist. J Med Chem. 2003;46 (1) :125-137.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ETA; ETB
Frequently Asked Questions
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