BMS-193884

BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].

Product Specifications

CAS Number

[176960-47-7]

UNSPSC

12352005

Target

Endothelin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bms-193884.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O

Molecular Formula

C20H17N3O4S

Molecular Weight

395.43

References & Citations

[1]Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[ (4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4- (2-oxazolyl) [1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET (A) selective antagonist. J Med Chem. 2003;46 (1) :125-137.