DPI-3290

DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively. DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity[1].

Product Specifications

CAS Number

182417-73-8

Product Name Alternative

Org 41793

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dpi-3290.html

Solubility

10 mM in DMSO

Smiles

O=C(N(C1=CC=CC(F)=C1)C)C2=CC=CC([C@@H](N3[C@@H](C)CN(CC=C)[C@H](C)C3)C4=CC=CC(O)=C4)=C2

Molecular Formula

C30H34FN3O2

Molecular Weight

487.61

References & Citations

[1]Gengo PJ, et al. DPI-3290 [ (+) -3- ((alpha-R) -alpha- ((2S,5R) -4-allyl-2,5-dimethyl-1-piperazinyl) -3-hydroxybenzyl) -N- (3-fluorophenyl) -N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. J Pharmacol Exp Ther. 2003 Dec;307 (3) :1221-6.