ONO-3307

ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases[1][2].

Product Specifications

CAS Number

[76472-29-2]

UNSPSC

12352005

Target

Kallikrein

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ono-3307.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1=CC=C(S(=O)(N)=O)C=C1)C2=CC=C(NC(N)=N)C=C2.CS(=O)(O)=O

Molecular Formula

C15H18N4O7S2

Molecular Weight

430.46

References & Citations

[1]Yoshikawa T, et al. Protective effects of ONO-3307, a new synthetic protease inhibitor against experimental disseminated intravascular coagulation in rats. Thromb Res. 1990 Oct 1;60 (1) :1-7.|[2]Matsuoka S, et al. Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51 (4) :455-63.