SM-2470

SM-2470 is a potent α1-adrenoceptor antagonist, has sympathetic nerve activity in anesthetized rats[1]. SM-2470 is an antihypertensive agent. SM-2470 exhibits hypocholesterolaemic effect by the inhibition of cholesterol absorption related to the reduction of cholesterol solubilization[2].

Product Specifications

CAS Number

[99899-45-3]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sm-2470.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(N(CC2)CCN2C(C3C(C=C4)CCC4C3)=O)=NC(C=C5OC)=C1C=C5OC.Cl

Molecular Formula

C23H30ClN5O3

Molecular Weight

459.97

References & Citations

[1]M Yoshioka, et al. Effect of SM-2470, a newly synthetized alpha 1-adrenoceptor antagonist, on sympathetic nerve activity in anesthetized rats. Arch Int Pharmacodyn Ther. May-Jun 1988;293:162-74.