Lactimidomycin

Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC50 value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities[1][2].

Product Specifications

CAS Number

[134869-15-1]

UNSPSC

12352005

Target

Dengue Virus; Flavivirus

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/lactimidomycin.html

Purity

99.90

Solubility

DMSO : 5.72 mg/mL (ultrasonic; warming)

Smiles

O=C(CC(C[C@@H](O)CC([C@@H](C)/C=C([C@@H]([C@@H](C)/C=C\C=C\CC/C=C/1)OC1=O)\C)=O)C2)NC2=O

Molecular Formula

C26H35NO6

Molecular Weight

457.56

References & Citations

[1]Schneider-Poetsch T, et al. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol. 2010 Mar;6 (3) :209-217.|[2]Carocci M, et al. Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Res. 2016 Apr;128:57-62.