Rel-Lifirafenib

Rel-Lifirafenib (rel-BGB-283) is the relative configuration of Lifirafenib (HY-18957) . Lifirafenib is a potent Raf Kinase and EGFR inhibitor[1].

Product Specifications

CAS Number

[1446090-77-2]

Product Name Alternative

Rel-BGB-283

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

EGFR; Raf

Type

Reference compound

Related Pathways

JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rel-lifirafenib.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=NC=CC(OC3=CC=C(O[C@]4([H])[C@@]5([H])[C@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.[Relativestereochemistry]

Molecular Formula

C25H17F3N4O3

Molecular Weight

478.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Tang Z, et al. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14 (10) :2187-97.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GTR15259530 1 Vial

Lentiviral mouse B3galt5 shRNA (UAS) - Lentiviral mouse B3galt5 shRNA (UAS) (100)

Ask

View Details

37674016 1.0 µg DNA

Prl2a1 ORF Vector (Rat) (pORF)

Ask

View Details

MBS1246316-01 0.02 mg (E-Coli)

Recombinant Staphylococcus aureus UPF0291 protein MW2494 (MW2494)

Ask

View Details

MBS1246316-02 0.1 mg (E-Coli)

Recombinant Staphylococcus aureus UPF0291 protein MW2494 (MW2494)

Ask

View Details

MBS1246316-03 0.02 mg (Yeast)

Recombinant Staphylococcus aureus UPF0291 protein MW2494 (MW2494)

Ask

View Details

MBS1246316-04 0.1 mg (Yeast)

Recombinant Staphylococcus aureus UPF0291 protein MW2494 (MW2494)

Ask

View Details