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VER-00158411

VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1].

Product Specifications

CAS Number

1174664-88-0

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ver-00158411.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN(CC2=CC=CC=C2)N=C1)NC(C=C3C(N4)=CC5=C4C=CC(OCC(C)(C)CN(C)C)=C5)=CNC3=O

Molecular Formula

C31H34N6O3

Molecular Weight

538.64

References & Citations

[1] Ann Gee Lisa OOI, et al. Combination therapy. 26 July 2018. WO2018136010A1

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Chk1; Chk2

Frequently Asked Questions

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