BCR-ABL-IN-2

BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.

Product Specifications

CAS Number

[897369-18-5]

UNSPSC

12352005

Target

Bcr-Abl

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BCR-ABL-IN-2.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1NCC2=C(C=C(N3N=C(C(C)(C)C)C=C3NC(NC4=CC=CC(Cl)=C4Cl)=O)C=C2)C1)O

Molecular Formula

C24H25Cl2N5O3

Molecular Weight

502.39

References & Citations

[1]Chan WW, et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell. 2011 Apr 12;19 (4) :556-68.|[2]ARYL SULFONOHYDRAZIDES. US 2008/0113967 A1.