1400W
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
Product Specifications
CAS Number
[180001-34-7]
Product Name Alternative
W1400
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; NO Synthase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/1400w.html
Purity
98.49
Solubility
10 mM in DMSO
Smiles
CC(NCC1=CC=CC(CN)=C1)=N
Molecular Formula
C10H15N3
Molecular Weight
177.25
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Available Sizes
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