P2X7-IN-2
P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].
Product Specifications
CAS Number
1058709-63-9
UNSPSC
12352005
Target
Interleukin Related; P2X Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/p2x7-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C)C=CC2=C1C=CN([C@H](C)CN)C2=O)CC3=CC=C(C(F)(F)F)C(F)=C3
Molecular Formula
C22H21F4N3O2
Molecular Weight
435.41
References & Citations
[1]Kelly, Michael G, et al. Preparation of isoquinolonecarboxamides as P2X7 purinoceptor modulators and uses thereof. WO2008112205 A1. 2008.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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