Enasidenib-d6
Enasidenib-d6 (AG-221-d6) is the deuterium labeled Enasidenib. Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively[2].
Product Specifications
CAS Number
2095569-76-7
Product Name Alternative
AG-221-d6
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C(C([2H])([2H])[2H])(O)CNC1=NC(NC2=CC=NC(C(F)(F)F)=C2)=NC(C3=CC=CC(C(F)(F)F)=N3)=N1
Molecular Formula
C19H11D6F6N7O
Molecular Weight
479.41
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
DUSP2, CT (DUSP2, PAC1, Dual specificity protein phosphatase 2, Dual specificity protein phosphatase PAC-1) (AP)
DUSP2, CT (DUSP2, PAC1, Dual specificity protein phosphatase 2, Dual specificity protein phosphatase PAC-1) (AP)
