Enasidenib-d6
Enasidenib-d6 (AG-221-d6) is the deuterium labeled Enasidenib. Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively[2].
Product Specifications
CAS Number
2095569-76-7
Product Name Alternative
AG-221-d6
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C(C([2H])([2H])[2H])(O)CNC1=NC(NC2=CC=NC(C(F)(F)F)=C2)=NC(C3=CC=CC(C(F)(F)F)=N3)=N1
Molecular Formula
C19H11D6F6N7O
Molecular Weight
479.41
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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PDIA6, ID (K159) (Protein Disulfide-isomerase A6, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, TXNDC7, PDIA6) (PE)
PDIA6, ID (K159) (Protein Disulfide-isomerase A6, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, TXNDC7, PDIA6) (PE)
GLS (glutaminase, AAD20, DKFZp686O15119, FLJ10358, GLS1, KIAA0838)
