TC-N 22A
TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].
Product Specifications
CAS Number
[1314140-00-5]
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc-n-22a.html
Solubility
10 mM in DMSO
Smiles
C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1
Molecular Formula
C14H13N5S
Molecular Weight
283.35
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18679/TC-N-22A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18679/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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