TC-N 22A
Product Specifications
UNSPSC Description
TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc-n-22a.html
Solubility
10 mM in DMSO
Smiles
C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1
Molecular Weight
283.35
References & Citations
[1]Sang-Phyo Hong, et al. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem. 2011 Jul 28;54(14):5070-81.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18679/TC-N-22A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18679/
Clinical Information
No Development Reported
CAS Number
1314140-00-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6472423-01 0.1 mL
DGKI, CT (Diacylglycerol Kinase iota, DAG Kinase iota, Diglyceride Kinase iota, DGK-iota) (MaxLight 550)
Ask
View Details 
MBS6472423-02 5x 0.1 mL
DGKI, CT (Diacylglycerol Kinase iota, DAG Kinase iota, Diglyceride Kinase iota, DGK-iota) (MaxLight 550)
Ask
View Details MBS1085285-01 0.05 mg (E-Coli)
Recombinant Halorhodospira halophila N-acetyl-gamma-glutamyl-phosphate reductase (argC)
Ask
View Details MBS1085285-02 0.05 mg (Yeast)
Recombinant Halorhodospira halophila N-acetyl-gamma-glutamyl-phosphate reductase (argC)
Ask
View Details