TC-N 22A

TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].

Product Specifications

CAS Number

[1314140-00-5]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tc-n-22a.html

Solubility

10 mM in DMSO

Smiles

C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1

Molecular Formula

C14H13N5S

Molecular Weight

283.35

References & Citations

[1]Sang-Phyo Hong, et al. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem. 2011 Jul 28;54 (14) :5070-81.