CP-465022 (maleate)

CP-465022 Maleate is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes[1][2].

Product Specifications

CAS Number

[199656-46-7]

UNSPSC

12352005

Hazard Statement

H302

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-465022-maleate.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CC=CC=C2Cl)C(/C=C/C3=NC(CN(CC)CC)=CC=C3)=NC4=C1C=C(F)C=C4.O=C(O)/C=C\C(O)=O

Molecular Formula

C30H28ClFN4O5

Molecular Weight

579.02

Precautions

P264-P270-P330-P501

References & Citations

[1]J T Lazzaro, et al. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology. 2002 Feb;42 (2) :143-53.