AD57 (hydrochloride)
AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src[1].
Product Specifications
CAS Number
2320261-72-9
UNSPSC
12352005
Target
Raf; RET; Ribosomal S6 Kinase (RSK) ; Src
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ad57-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C3=NN(C(C)C)C4=C3C(N)=NC=N4)C=C2.[H]Cl
Molecular Formula
C22H21ClF3N7O
Molecular Weight
491.90
References & Citations
[1]Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 6;486 (7401) :80-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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