Filgotinib-d4
Filgotinib-d4 is the deuterium labeled Filgotinib. Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Product Specifications
CAS Number
2041095-50-3
Product Name Alternative
GLPG0634-d4
UNSPSC
12352005
Target
JAK
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Purity
0.98
Solubility
10 mM in DMSO
Smiles
O=C(C1C([2H])([2H])C1([2H])[2H])NC2=NN3C(C4=CC=C(C=C4)CN5CCS(=O)(CC5)=O)=CC=CC3=N2
Molecular Formula
C21H19D4N5O3S
Molecular Weight
429.53
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Menet CJ, et al. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J Med Chem. 2014 Nov 17.|[3]Van Rompaey L, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013, 191 (7), 3568-3577.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
32328064 1.0 µg DNA
NUP35 Lentiviral Vector (Mouse) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details 
CSB-EP318842MO-01 10 µg
Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1)
Sign In for Pricing
View Details CSB-EP318842MO-02 50 µg
Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1)
Sign In for Pricing
View Details CSB-EP318842MO-03 200 µg
Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1)
Sign In for Pricing
View Details CSB-EP318842MO-04 500 µg
Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1)
Sign In for Pricing
View Details