NSC 33994
NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].
Product Specifications
CAS Number
[82058-16-0]
UNSPSC
12352005
Target
Autophagy; JAK
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-33994.html
Solubility
10 mM in DMSO
Smiles
CC/C(C1=CC=C(O)C(CN(CC)CC)=C1)=C(C2=CC=C(O)C(CN(CC)CC)=C2)/CC
Molecular Formula
C28H42N2O2
Molecular Weight
438.65
References & Citations
[1]Róbert Kiss, et al. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3598-601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2
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